Hexafluoroisopropanol: a powerful solvent for the hydrogenation of indole derivatives. Selective access to tetrahydroindoles or cis-fused octahydroindoles.
نویسندگان
چکیده
Pd/C in HFIP was used to hydrogenate indole derivatives under relatively mild conditions, leading to potential synthetic intermediates of bioactive compounds. Depending on their substitution, tetrahydroindoles or octahydroindoles could selectively be obtained.
منابع مشابه
A fast, simple and convenient procedure for the synthesis of fused pyrimidinone derivatives by using [Hmim][HSO4] as a green, efficient and reusable catalyst under solvent-free conditions
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In the present of methylimidazolium hydrogen sulfate, the synthesis of arylidene heterobicyclic pyrimidinones is studied by condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. Using solvent-free conditions, non-toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 32 شماره
صفحات -
تاریخ انتشار 2012